Hill Top Research has been conducting standard setting dermatology research for 70 years. Hill Top/Cliantha has the combined ability to conduct Phase I patch studies in the US, Canada, and India.
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With our DermRx division in North America and in India, we are able to conduct a wide variety of safety and efficacy trials for topical and transdermal drugs products. These trials can be conducted in a controlled in-house environment or on an outpatient basis. Cliantha/Hill Top has amassed a wide variety of specialty scientific instruments used in the conduct of our dermatology and personal healthcare trials.
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Phase I Safety Trials
- Acute Irritation or Primary Irritation (24-hour and 48-hour patch test)
- Cumulative Irritation (14 day and 21day)
- Contact Sensitization (Human Repeat Insult Patch Test [HRIPT])
- Phototoxicity
- Patch Testing
- Photo-allergy
- Pharmacokinetic Studies with capacity to house up to 48 subjects
- Transdermal delivery systems (irritation, sensitization, adhesion)
- Transdermal Patch Cold Flow Studies
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Efficacy Trials
- Dermatology
- Acne
- Actinic Keratosis
- Atopic dermatitis
- Eczema
- Head Lice, Scabies
- Onychomycosis
- Psoriasis
- Rosacea
- Seborrheic dermatitis
- Transdermal Systems.
- Lidocaine
- Fentanyl
- Rotigotine
- Buprenorphine
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- Hormone replacement therapy
- Smoking cessation
- Taste testing
- Topical antibiotics
- Vasoconstriction
- Wound healing
- Cold Sores, Herpes Labialis
- Spontaneous
- UV light induced
- Diaper Rash
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Specialty Trials
Hill Top Research has extensive expertise with New Chemical Entities (NCE) and Bioequivalence with the following study types:
- Contact Sensitization (Human Repeat Insult Patch Test [HRIPT])
- Transdermal and Topical Bioequivalence
- Skin Blanching - Vasoconstrictor Studies
- Wear Studies
- Cumulative Irritation (14 and 21 day studies)
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Our Legacy Research
Hill Top Research has a legacy of 70 years planning, conducting and analyzing Dermatology studies for pharmaceutical, biotechnology, generic and personal healthcare companies. We have expertise in conducting the following clinical research.
- Patch testing (primary and cumulative irritation, sensitization)
- Vasoconstriction (Skin Blanching)
- Phototoxicity and photo allergy
- Comedogenicity
- Antiperspirant and deodorant*
- Anti-aging
- Hyperhidrosis Laser Treatment
- Skin Biopsies
- Skin lightening
- Pediatric (diaper rash, disposable diapers/wipes, safety, infant eczema, product taste test)
- Acne (cosmetic cleansing, anti-acne studies, OTC and Rx acne product studies and trials)
- Sunscreen safety, durability and use trials in both adults and children
- Mildness/moisturization (FCAT/LCAT studies, long- and short-term dry skin/moisturization)
- Feminine hygiene (tampon and incontinence)
- Cold sore, Herpes Labialis (naturally occurring and UVR-induced)
- Head lice
- Ocular safety (sting and instillation for topical products, home-use for cosmetics)
- Wound care/wound healing (dermabrasion model, incisional wounds, tape-stripping, and SLS challenge)
- Dry mouth
- Cyberceuticals
- Footwear, Athletic Clothing testing.
- Fitness Wristbands and "wearables"
- Chapped lips
- Cleansing Efficacy (make-up removal)
- Exfoliation
- Cosmetic Use
- Foot care, cracked heel
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We offer Board Certified PI's in Ophthalmology, Dermatology, Podiatry, Pediatrics, Family Practice, OB/GYN.
Our Medical Director and Associate Medical Director are also Certified Principal Investigators by ACRP.
We have experience with Device Studies.
*Our Deodorant studies have included as many as 110 subjects as a single group in a validated, regulated, environmentally controlled chamber. We have 5 HTR trained qualified "odor" judges.
In addition to the above we can offer consulting services in Dermatology for HRIPT, Vasoconstrictor Assay Study and we assist with the R&D process, research strategy, planning, study design, equipment, protocol writing, randomization scheme generations, biostatistics, report writing and over all submissions.
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