Dermatology Rx


Hill Top Research has been conducting standard setting dermatology research for 70 years. Hill Top/Cliantha has the combined ability to conduct Phase I patch studies in the US, Canada, and India.

With our DermRx division in North America and in India, we are able to conduct a wide variety of safety and efficacy trials for topical and transdermal drugs products. These trials can be conducted in a controlled in-house environment or on an outpatient basis. Cliantha/Hill Top has amassed a wide variety of specialty scientific instruments used in the conduct of our dermatology and personal healthcare trials.

Phase I Safety Trials

  • Acute Irritation or Primary Irritation (24-hour and 48-hour patch test)
  • Cumulative Irritation (14 day and 21day)
  • Contact Sensitization (Human Repeat Insult Patch Test [HRIPT])
  • Phototoxicity
  • Patch Testing
  • Photo-allergy
  • Pharmacokinetic Studies with capacity to house up to 48 subjects
  • Transdermal delivery systems (irritation, sensitization, adhesion)
  • Transdermal Patch Cold Flow Studies

Efficacy Trials

  • Dermatology
    • Acne
    • Actinic Keratosis
    • Atopic dermatitis
    • Eczema
    • Head Lice, Scabies
    • Onychomycosis
    • Psoriasis
    • Rosacea
    • Seborrheic dermatitis

  • Transdermal Systems.
    • Lidocaine
    • Fentanyl
    • Rotigotine
    • Buprenorphine

 

  • Hormone replacement therapy
  • Smoking cessation
  • Taste testing
  • Topical antibiotics
  • Vasoconstriction
  • Wound healing
  • Cold Sores, Herpes Labialis
    • Spontaneous
    • UV light induced
  • Diaper Rash

Specialty Trials


Hill Top Research has extensive expertise with New Chemical Entities (NCE) and Bioequivalence with the following study types:

  • Contact Sensitization (Human Repeat Insult Patch Test [HRIPT])
  • Transdermal and Topical Bioequivalence
  • Skin Blanching - Vasoconstrictor Studies
  • Wear Studies
  • Cumulative Irritation (14 and 21 day studies)

Our Legacy Research


Hill Top Research has a legacy of 70 years planning, conducting and analyzing Dermatology studies for pharmaceutical, biotechnology, generic and personal healthcare companies. We have expertise in conducting the following clinical research.

  • Patch testing (primary and cumulative irritation, sensitization)
  • Vasoconstriction (Skin Blanching)
  • Phototoxicity and photo allergy
  • Comedogenicity
  • Antiperspirant and deodorant*
  • Anti-aging
  • Hyperhidrosis Laser Treatment
  • Skin Biopsies
  • Skin lightening
  • Pediatric (diaper rash, disposable diapers/wipes, safety, infant eczema, product taste test)
  • Acne (cosmetic cleansing, anti-acne studies, OTC and Rx acne product studies and trials)
  • Sunscreen safety, durability and use trials in both adults and children
  • Mildness/moisturization (FCAT/LCAT studies, long- and short-term dry skin/moisturization)
  • Feminine hygiene (tampon and incontinence)
  • Cold sore, Herpes Labialis (naturally occurring and UVR-induced)
  • Head lice
  • Ocular safety (sting and instillation for topical products, home-use for cosmetics)
  • Wound care/wound healing (dermabrasion model, incisional wounds, tape-stripping, and SLS challenge)
  • Dry mouth
  • Cyberceuticals
  • Footwear, Athletic Clothing testing.
  • Fitness Wristbands and "wearables"
  • Chapped lips
  • Cleansing Efficacy (make-up removal)
  • Exfoliation
  • Cosmetic Use
  • Foot care, cracked heel

We offer Board Certified PI's in Ophthalmology, Dermatology, Podiatry, Pediatrics, Family Practice, OB/GYN.

Our Medical Director and Associate Medical Director are also Certified Principal Investigators by ACRP.

We have experience with Device Studies.

*Our Deodorant studies have included as many as 110 subjects as a single group in a validated, regulated, environmentally controlled chamber. We have 5 HTR trained qualified "odor" judges.
In addition to the above we can offer consulting services in Dermatology for HRIPT, Vasoconstrictor Assay Study and we assist with the R&D process, research strategy, planning, study design, equipment, protocol writing, randomization scheme generations, biostatistics, report writing and over all submissions.



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